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KMID : 0363220150530070542
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Korean Journal of Dermatology
2015 Volume.53 No. 7 p.542 ~ p.545
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A Case of Drug Eruption Similar to Erythema Multiforme Induced by Sorafenib
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Oh Won-Jong
Ko Eun-Jung
Choi Sun-Young
Park Kui-Young
Li Kap-Sok
Kim Beom-Joon
Seo Seong-Jun
Kim Myeung-Nam
Hong Chang-Kwun
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Abstract
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Sorafenib is an oral multi-kinase inhibitor with effects on tumor cell proliferation and tumor angiogenesis. The drug is associated with a relatively high incidence of dermatologic adverse events. Frequently observed clinical presentations include skin rash, a hand-foot skin reaction, alopecia, splinter subungual hemorrhages, and xerosis. There have been few reports of erythema multiforme or leukocytoclastic vasculitis related to sorafenib use. We report a case of a 72 year-old male diagnosed with renal cell carcinoma with distant metastasis, who developed an erythema multiforme-like drug eruption on his trunk and extremities after use of sorafenib.
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KEYWORD
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Drug eruption, Erythema multiforme, Sorafenib
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